Larry H Matherly Selected Research

Down Syndrome (Down's Syndrome)

1/2013	Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia.
1/2011	A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.
2/2006	Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.
2/2005	GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
1/2004	The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.
2/2003	Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines.

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Larry H Matherly Research Topics

Disease

57	Neoplasms (Cancer) 12/2023 - 01/2003
10	Leukemia 12/2023 - 04/2002
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023 - 02/2003
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2020 - 12/2010
6	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2014 - 02/2004
6	Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic) 01/2013 - 02/2003
6	Down Syndrome (Down's Syndrome) 01/2013 - 02/2003
4	Ovarian Epithelial Carcinoma 02/2024 - 01/2017
4	Hereditary Folate Malabsorption 10/2022 - 01/2009
3	Ovarian Neoplasms (Ovarian Cancer) 02/2024 - 01/2019
3	Malignant Mesothelioma 01/2020 - 04/2013
2	Mesothelioma 01/2020 - 12/2012
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2014 - 02/2010
2	Epilepsy (Aura) 12/2012 - 11/2010
2	Colorectal Neoplasms (Colorectal Cancer) 11/2009 - 02/2008
1	Acquired Immunodeficiency Syndrome (AIDS) 05/2022
1	Carcinogenesis 01/2022
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Inflammation (Inflammations) 03/2019
1	Adenocarcinoma of Lung 10/2018
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2012
1	Breast Neoplasms (Breast Cancer) 04/2012

Drug/Important Bio-Agent (IBA)

31	Folic Acid AntagonistsIBA 12/2023 - 01/2003
25	Folic Acid (Vitamin M)FDA LinkGeneric 12/2023 - 01/2008
24	Proton-Coupled Folate TransporterIBA 12/2023 - 01/2009
20	pyrimidineIBA 12/2023 - 10/2010
14	Reduced Folate Carrier ProteinIBA 12/2023 - 02/2004
14	purineIBA 12/2023 - 10/2010
13	Pemetrexed (MTA)FDA Link 12/2023 - 03/2007
10	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 02/2004
9	Proteins (Proteins, Gene)FDA Link 05/2022 - 10/2003
9	NucleotidesIBA 01/2022 - 12/2012
8	CarbonIBA 02/2024 - 03/2019
8	Hydroxymethyl and Formyl TransferasesIBA 02/2024 - 10/2011
7	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2023 - 02/2003
7	glycinamide ribonucleotideIBA 01/2021 - 10/2011
5	EnzymesIBA 01/2021 - 01/2007
5	DNA (Deoxyribonucleic Acid)IBA 04/2020 - 04/2002
5	Protons (Proton)IBA 10/2016 - 10/2010
4	SymportersIBA 10/2016 - 10/2010
4	Glutamic Acid (Glutamate)FDA Link 02/2012 - 08/2008
3	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 11/2020 - 10/2019
3	Folic Acid TransportersIBA 03/2019 - 03/2007
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 08/2013 - 10/2003
2	Cisplatin (Platino)FDA LinkGeneric 02/2024 - 01/2017
2	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 02/2024 - 11/2020
2	ME-344IBA 12/2023 - 04/2023
2	venetoclaxIBA 12/2023 - 04/2023
2	IsoflavonesIBA 12/2023 - 04/2023
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2013
2	RibonucleotidesIBA 01/2021 - 01/2020
2	ThiophenesIBA 01/2021 - 02/2010
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2020 - 10/2019
2	Adenosine Triphosphate (ATP)IBA 11/2020 - 10/2019
2	PyrimidinesIBA 12/2019 - 05/2009
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 10/2018 - 04/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 10/2018 - 04/2014
2	TensinsIBA 08/2013 - 02/2010
2	Histone Deacetylase InhibitorsIBA 12/2012 - 11/2010
2	Valproic Acid (Depakote)FDA LinkGeneric 12/2012 - 11/2010
2	EstersIBA 10/2011 - 02/2010
2	Polyglutamic Acid (Polyglutamate)IBA 01/2008 - 03/2007
2	Arabinofuranosylcytosine TriphosphateIBA 02/2005 - 01/2004
2	Cytidine DeaminaseIBA 02/2005 - 01/2004
2	Complementary DNA (cDNA)IBA 02/2005 - 08/2004
1	Serine (L-Serine)FDA Link 02/2024
1	ProteomeIBA 05/2022
1	CholesterolIBA 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022
1	LipidsIBA 01/2022
1	furanIBA 01/2021
1	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 01/2021
1	CytosineIBA 04/2020
1	Cadherins (E-Cadherin)IBA 04/2020
1	fluorocyclopentenylcytosineIBA 04/2020
1	Lactate Dehydrogenase 5IBA 01/2020
1	SulfurIBA 01/2020
1	S 6 (S-6)IBA 01/2020
1	Aligeron (AS 2)IBA 01/2020
1	AmidesIBA 12/2019
1	NAD (NADH)IBA 10/2019
1	Propoxur (Baygon)IBA 09/2019
1	Chimeric Antigen ReceptorsIBA 03/2019
1	beta-Galactosidase (Lactaid)IBA 10/2018
1	FluorineIBA 10/2018
1	10-propargyl-10-deazaaminopterin FDA Link 04/2014
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2014
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2014
1	Notch1 ReceptorIBA 08/2013
1	Clofarabine (Clolar)FDA Link 12/2012
1	Purine NucleosidesIBA 12/2012
1	AminopterinIBA 09/2012
1	2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA 04/2012
1	Blood Proteins (Serum Proteins)IBA 04/2012

Therapy/Procedure

16	Drug Therapy (Chemotherapy) 12/2023 - 12/2003
15	Therapeutics 12/2023 - 03/2007
1	Immunotherapy 10/2018